In episode 139 of Game Design Unboxed, we chat with Jade Shames and Ben Bronstein, co-founders of Pillbox Games and co-designers of this episode’s spotlight game, Side Effects.

They talk about how a mental illness–inspired card game idea (later titled Side Effects) sparked their collaboration and company, the power of bold visuals, why skeletons make perfect models, the balance between realism and accessibility, adjusting setup rules for varying player counts, and being innovative when it comes to product design for your games.

They also discuss homebrew variants, the all-too-familiar and disturbing medical side-effect warnings in commercials, and the hope that, if a misprint or typo occurs in print, it might become a collectible one day!